![]() Key facts about the olfactory nerve and pathway It will highlight some of the unique characteristics of certain cells within the olfactory pathway, and the connection of the pathway to memory (and behavior) related brain regions. To understand the olfactory nerve and its clinical implications, this article will trace the olfactory nerve from its receptor cells, located in the nasal epithelium, to the olfactory cortex and beyond. A decreased sense of smell has been associated with Parkinson’s disease and thus, can be an important clinical marker in this and other states of disease or injury. The odor information originates in the epithelium of the nasal cavity and is transported to the brain via components of the olfactory nerve (cranial nerve 1 - CNI) and the olfactory pathway. In this case, the olfactory nerve is responsible for our sense of smell. ![]() The olfactory nerve is the first of the 12 cranial nerves and one of the few cranial nerves that carries special sensory information only. Sensations perceived by the body are organized into two major groups: general sensations such as touch, pressure, pain, and temperature, and special sensations such as vision, hearing, taste, smell, and the sense of body position and movement.
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